ämnen allotransplantation Transplantimmunologi Abstrakt CD47-deficient hepatocyttransplantation inducerar snabb medfödd immuncellsaktivering och

By FISH, Lindberg et al. (1994) mapped the CD47 gene to chromosome 3q13.1-q13.2. Animal Model Lindberg et al. (1996) made observations in gene-targeted mice indicating that integrin-associated protein plays a key role in host defense by participating both in polymorphonuclear migration in response to bacterial infection and in polymorphonuclear activation at extravascular sites.

CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. CD47 cloned gene : ORF from ATG to Stop, in pUNO1 expression plasmid selectable in E.coli and mammalian cells. Fully sequenced.

GO annotations related to this gene include thrombospondin receptor activity . lnc-CD47-10: RNA Gene: 4: GC03M107935: 6.73: 14: RHD: Rh Blood Group D Antigen: Protein Coding: 42: GC01P025272: 6.30: 15: LINC00636: Long Intergenic Non-Protein Coding RNA 636: RNA Gene: 17: GC03P107883: 6.26: 16: PTPN11: Protein Tyrosine Phosphatase Non-Receptor Type 11: Protein Coding: 54: GC12P112418: 6.22: 17: CD44: CD44 Molecule (Indian Blood Group) Protein Coding: 48: … CD47 - Integrin-associated protein - Homo sapiens (Human) - CD47 gene & protein UniProtKB - A0A0A1TSG4 (A0A0A1TSG4_HUMAN) Summary of CD47 (IAP, MER6, OA3) expression in human tissue. Cytoplasmic and membranous expression in several tissues. 2020-09-24 The gene view histogram is a graphical view of mutations across CD47. These mutations are displayed at the amino acid level across the full length of the gene by default.

CD47. Gene descriptioni.

Associated products · Compatible Secondaries · Isotype control · Positive Controls · Recombinant Protein.

The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal CD47 CD47 molecule Gene ID: 961, updated on 7-Mar-2021 Gene type: protein coding Also known as: IAP; OA3; MER6. Go to complete Gene record for CD47; Go to Variation Viewer for CD47 variants; Summary This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.

Brist på samband mellan genetisk variation i g-protein-kopplad receptor för Blockering av CD47 ökar överlevnaden hos möss exponerade för dödlig total

Go to complete Gene record for CD47; Go to Variation Viewer for CD47 variants; Summary This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Gene name: CD47 (HGNC Symbol) Synonyms: IAP, MER6, OA3: Description: CD47 molecule (HGNC Symbol) Chromosome: 3: Cytoband: q13.12: Chromosome location (bp) 108043094 - 108091862: Number of transcripts i Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by annexin/propidium iodide flow assays. 2020-12-01 · HIF-1 directly bound with the promoter of CD47 to activate gene transcription and increased cell surface CD47 in HCC1954 and SUM159 breast cancer cells . Moreover, macrophage phagocytosis rate was significantly increased when co-cultured with HIF-1-deficient breast cancer cells [ 43 ], indicating that HIF-1 plays a pivotal role in regulation of CD47 expression. The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand.

Gene name. CD47 (HGNC Symbol) Synonyms.
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-0.40. NCCRP1. 0.18.

CD47 is similar to these genes: Galectin-3, Dermatopontin, BCAR1 and more.
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The gene view histogram is a graphical view of mutations across CD47_ENST00000355354. These mutations are displayed at the amino acid level across the full length of the gene by default.

är grundläggande för att upprätta ett korrekt antal immunceller, så kallade B-lymfocyter, enligt en ny avhandling. Expression and Regulation of the Cell Surface Proteins CD47 and SIRPα in Resident Expression of weight and aggression regulating genes in Drosophila proteinbearbetning och vikning (CANX, PSENEN) och det integrin-associerade protein, CD47, som modulerar cellaktivering och vidhäftning. of using gene therapy to prevent and/or ameliorate autoimmune diseases. Mattias Olsson (Midterm seminar), Umeå university, “Role of the CD47/SIRPα (73) BioNTech Cell & Gene Therapies GmbH, An der Goldgrube (54) ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF.

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CD47 - Integrin-associated protein - Homo sapiens (Human) - CD47 gene & protein UniProtKB - A0A0A1TSG4 (A0A0A1TSG4_HUMAN)

Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. CD47.

H89 and protein kinase A (PKA) inhibitor peptide prevented rescue of breast cancer cells by PTX, 8-Br-cAMP, and forskolin, suggesting that the effects of cAMP are

Go to complete Gene record for CD47; … CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels.

ämnen allotransplantation Transplantimmunologi Abstrakt CD47-deficient hepatocyttransplantation inducerar snabb medfödd immuncellsaktivering och presence of IgG or anti-CD47 B6H12 (blocking) or 2D3 (nonblocking) mAbs.